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AOD-9604

 

 

AOD-9604 ANTI OBESITY DRUG

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AOD9604 is a modified version of the hGH fragment 176-191 peptide (contains a di-sulfide bridge) and thus a derivative of human growth hormone (hGH). Originally developed as a lipolytic (fat burning) compound, AOD9604 has shown benefit in studies of heart disease, osteoarthritis/cartilage repair, and metabolic syndrome. AOD9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis in animal studies.

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AOD 9604 is a synthetic peptide derived from human growth hormone (HGH) that has been studied for its potential anti-obesity effects. Here are 20 potential benefits associated with AOD 9604:

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  • Fat Loss: AOD 9604 has been shown to promote fat burning and aid in weight loss, particularly targeting adipose (fat) tissue.

  • Increased Metabolism: AOD 9604 may help boost metabolic rate, leading to increased calorie burning and potential improvements in weight management.

  • Reduced Fat Accumulation: AOD 9604 may inhibit the formation and accumulation of new fat cells, helping to prevent weight gain.

  • Appetite Control: AOD 9604 has been reported to help suppress appetite and reduce food cravings, supporting healthier eating habits.

  • Improved Insulin Sensitivity: AOD 9604 has shown potential in enhancing insulin sensitivity, which can be beneficial for managing blood sugar levels and reducing the risk of metabolic disorders.

  • Enhanced Lipid Profile: AOD 9604 may have positive effects on lipid metabolism, leading to improvements in cholesterol levels and overall lipid profile.

  • Preservation of Lean Muscle Mass: AOD 9604 may help preserve lean muscle mass during weight loss, preventing muscle wasting.

  • Increased Energy Expenditure: AOD 9604 can enhance energy expenditure, allowing for more efficient calorie utilization and potentially boosting overall energy levels.

  • Enhanced Recovery from Exercise: AOD 9604 has been reported to support faster recovery from physical activity and reduce exercise-induced muscle damage.

  • Improved Bone Health: AOD 9604 may have positive effects on bone mineral density, potentially improving bone health and reducing the risk of osteoporosis.

  • Anti-inflammatory Effects: AOD 9604 exhibits anti-inflammatory properties, potentially reducing inflammation in the body and supporting overall health.

  • Joint Health Support: AOD 9604 may aid in the repair and regeneration of joints, potentially improving joint health and reducing pain.

  • Cardiovascular Health Benefits: AOD 9604 may have positive effects on cardiovascular health, including improved heart function and potential reductions in blood pressure.

  • Enhanced Recovery from Injuries: AOD 9604 has shown potential in supporting the healing process of injuries, potentially speeding up recovery.

  • Skin Health and Repair: AOD 9604 may promote collagen synthesis, leading to improved skin elasticity, reduced wrinkles, and enhanced wound healing.

  • Anti-aging Effects: AOD 9604 may have anti-aging benefits, including the potential reduction of age-related symptoms and improvements in overall vitality.

  • Cognitive Function Enhancement: Some studies suggest that AOD 9604 may have positive effects on cognitive function, including memory and focus.

  • Potential Anti-inflammatory Effects on Digestive System: AOD 9604 may help reduce inflammation in the digestive system, potentially benefiting individuals with digestive disorders.

  • Regulation of Lipid Metabolism: AOD 9604 may help regulate lipid metabolism, supporting healthy lipid levels and metabolism.

  • Overall Health and Well-being: The combination of the above benefits can contribute to an improved overall health, vitality, and well-being.

 

It's important to note that AOD 9604 is still undergoing research, and more studies are needed to fully understand its mechanisms of action and potential long-term effects. It's always recommended to consult with a healthcare professional before considering any peptide therapy or supplementation.

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National Library of Medicine

National Center of Biotechnology Infornation

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https://pubmed.ncbi.nlm.nih.gov/11146367/ 

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https://pubmed.ncbi.nlm.nih.gov/11713213/ 

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https://pubmed.ncbi.nlm.nih.gov/11673763/

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https://pubmed.ncbi.nlm.nih.gov/10950816/ 

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https://pubmed.ncbi.nlm.nih.gov/11116208/

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https://pubmed.ncbi.nlm.nih.gov/16644234/

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Journal of Endocrinology & Metabolism

"Animal experiments confirmed the fat reducing potential of AOD9604, which seems to act directly on fat metabolism without influencing appetite. In genetically obese strains of rats and mice, AOD9604 was shown to affect body weight reduction, stimulation of lipolysis and inhibition of lipogenesis. Adverse effects, as seen in similar studies using intact hGH [182021], were not observed with AOD9604 supplementation"

 

Acknowledgments

Dr Evert Vos and Dr Caroline Herd 

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